Persistent generalized Grover disease: complete remission after treatment with oral acitretin.

Grover disease (GD) is a disorder of unknown origin, clinically characterized by the occurrence of pruritic, erythematous or brownish papules and papulovesicles, which histologically reveal four different patterns of acantholysis. Usually, the eruption is self-limited and spontaneously remit within a few weeks. In some cases, however, it may persist for months or even years and show a therapy-resistant course. We report a 56-year-old woman with recalcitrant, persistent, and generalized GD who showed complete remission after 6 weeks of treatment with oral acitretin (0.8mg/kg/day). The treatment was well-tolerated and laboratory parameters remained unchanged. The patient remains free of any recurrence at 26 months. To the best of our knowledge, this is the first report of a complete remission of the persistent form of GD as a result of oral acitretin monotherapy.

Loss of mismatch repair protein expression in breast carcinoma in patients with Lynch Syndrome: report of two cases.

Lynch Syndrome, an autosomal dominantly inherited cancer predisposition syndrome is not typically associated with development of breast cancer. We present two cases of loss of mismatch protein expression in breast cancer cases in patients with Lynch Syndrome and discuss the literature surrounding the subject.